I don't follow anything Facebook, so I'm not exactly sure what the joke about Zuckerberg being badly dubbed and making sound effects was about.
Same, I've never actually heard Zuckerberg talk, so I didn't know if they were making fun of his voice, or what the whole "You can't block me!" thing was. I really just assumed they phoned this one in, and just took the previous "Coon and Friends" superhero commercial and spliced in some quickly dubbed meme-type jokes about Zuckerberg and Fake News to make it topical.
Edit: Cartman's superhero name is censored.
Edited, Oct 12th 2017 10:13am by TirithRR